Prognostic significance of expression of cyclooxygenase-2 and vascular endothelial growth factor in human gastric carcinoma

Table 4 Risk factors affecting survival determined by multivariate analysis using the Cox proportional hazards model

Variables	Regression coefficient	Standard error	Odds ratio (95% confidence interval)	P value
Histology (differentiated/undifferentiated)	0.564	0.337	1.758 (1.583-2.147)	NS
Depth of invasion (EGC/muscularis propria)	0.524	0.248	1.688 (1.638-1.714)	< 0.05
Lymph node metastasis (present/absent)	0.796	0.1934	2.220 (1.518-3.239)	< 0.01
Vascular invasion (present/absent)	0.413	0.213	2.003 (1.499-2.460)	< 0.01
COX-2 expression (positive/negative)	0.776	0.194	2.173 (1.486-3.178)	< 0.01
VEGF expression (positive/negative)	1.071	0.254	2.917 (1.774-4.796)	< 0.01

Note: NS, not significant.