Synergistic effects of nimesulide and 5-fluorouracil on tumor growth and apoptosis in the implanted hepatoma in mice

Table 1 Effect of nimesulide and 5-FU on tumor inhibition in mouse implanted hepatomas (n = 10, ^-x±s)

Group	X1	R1	X2	R2
Control	3.67 ± 1.7	-	3.69 ± 1.6	-
Nimesulide 20 mg/kg	2.59 ± 0.9c	30%	2.56 ± 0.9c	31%
5-FU 10 mg/kg	2.63 ± 0.9c	28%	2.61 ± 1.0c	29%
5-FU 20 mg/kg	1.11 ± 0.6ab	70%	1.01 ± 0.6ab	73%
Nimesulide 20 mg/kg + 5-FU 10 mg/kg	0.43 ± 0.2a	88%	0.49 ± 0.2a	87%

^aP < 0.01 vs control,

^bP < 0.05,

^cP < 0.01 vs nimesulide + 5-FU. X1: the first mean tumor weights; R1: the first mean inhibition rates; X2: the second mean tumor weights; R2: the second mean in-hibition rates.