Anti-Helicobacter pylori immunoglobulin G (IgG) and IgA antibody responses and the value of clinical presentations in diagnosis of Helicobacter pylori infection in patients with precancerous lesions

Table 3 Comparison of serum anti-H. pylori IgG and IgA levels (the optical density value) at different stages of CG

	Mild CAG		Severe CAG		Mild IM		Severe IM		DYS
	H. pylori (+)	H. pylori (-)	H. pylori (+)	H. pylori (-)	H. pylori (+)	H. pylori (-)	H. pylori (+)	H. pylori (-)	H. pylori (+)	H. pylori (-)
IgG (1)	2.86 ± 1.8b	0.38 ± 0.27	4.48 ± 2.14bc	0.53 ± 0.27	3.86 ± 1.87b	0.14 ± 0.07	3.1 ± 2.34a	0.55 ± 0.29d	2.74 ± 1.67b	0.23 ± 0.17
IgG (2)	3.26 ± 2.16b	0.46 ± 0.24	4.52 ± 3.27a	0.54 ± 0.29	4.44 ± 2.56b	0.3 ± 0.18	3.5 ± 1.98b	0.54 ± 0.29	3.33 ± 1.87b	0.72 ± 0.97
IgA (1)	0.85 ± 0.7b	0.24 ± 0.22	0.99 ± 0.49b	0.21 ± 0.16	0.83 ± 0.39b	0.1 ± 0.06	0.93 ± 0.79	0.33 ± 0.16d	0.94 ± 0.89b	0.13 ± 0.13
IgA (2)	0.96 ± 0.83b	0.25 ± 0.21	1.08 ± 0.59a	0.27 ± 0.16	0.99 ± 0.72a	0.12 ± 0.07	0.89 ± 0.63a	0.32 ± 0.19d	0.78 ± 0.6b	0.15 ± 0.13

CAG, chronic atrophic gastritis; IM, intestinal metaplasia; DYS, dysplasia. (1) The first detection. (2) The second detection.

^aP < 0.01,

^bP < 0.001, H. pylori (+) vs. H. pylori (-).

^cP < 0.05, H. pylori (+) mild CAG vs. H. pylori (+) severe CAG;

^dP < 0.05, H. pylori (-) mild IM vs. H. pylori (-) severe IM.