Preventive treatments for recurrence after curative resection of hepatocellular carcinoma - A literature review of randomized control trials

Table 5 Summary of RCTs of Interferon treatment

Authors	Entry criteria	Tx protocol	Sample size	Observation time	DFS	OS	Conclusions
					Tx vs Ctl	Tx vs Ctl
Ikeda[35]	Complete remove by	IFNβ 6MU im	20 (10/10)	2-34.6 months	1 year	NA	Beneficial
	resection or PEI	biw × 36 months			0% vs 62.5%
Kubo[14,36]	Complete remove,	IFNα 6MU biw × 2	30 (15/15)	1817 days (Tx)	Recurrence	NA	Beneficial
	negative in CT scan 3-4	weeks then tiw × 14		and 1487 (Ctl)	9/15 vs 13/15
	weeks after operation	weeks then biw × 88 weeks			P = 0.041