Preventive treatments for recurrence after curative resection of hepatocellular carcinoma - A literature review of randomized control trials

Table 1 The important issues related to evaluation of efficacy of prevention of recurrence

Authors	Average tumor size	Definition of curative resection			1 year RR	1 year DFS	1 year OS
		Complete removal in operation	Negative in histology on surgical margin	Negative in post-operative exams
Kubo	2.6 cm	Yes	No	Yes	25%a	NA	92%
Lau	3.8 cm	Yes	Yes	No	NA	59.1%	86.4%
Tang	< 5 cm, complete tumor	Yes	Yes	No	6.5%	NA	NA
	capsule, without portal
	vein involvement
Poon[12]	> 5 cma	Yes	No	No	46%	NA	55.5%
Izumi[6]	> 5 cma	Yes	No	No	51.7%	43.0%	81.0%
Lai[8]	10.4 cm	Yes	No	Yes	20%-30%	69.0%	75%*

RR: Recurrence rate; DFS: Disease free survival; OS: Overall survival; NA: Data not available.

^aestimated according to the authors’ paper.