Oxidative DNA damage in peripheral leukocytes and its association with expression and polymorphisms of hOGG1: A study of adolescents in a high risk region for hepatocellular carcinoma in China

doi:10.3748/wjg.v9.i10.2186

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Oct 15, 2003 (publication date) through May 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Oct 15, 2003; 9(10): 2186-2193
Published online Oct 15, 2003. doi: 10.3748/wjg.v9.i10.2186

Table 4 Multiple regression models of predictors on levels of oxidative DNA damage biomarkers

Predictors in the model	Double staining percentage (%)		8-oxoGP		8-oxoGI		hOGG₁P		hOGG₁I
Predictors in the model	Beta^b	P	Beta	P	Beta	P	Beta	P	Beta	P
8-oxoGP							0.463		0.000^c
8-oxoGI	0.521	0.000^c							131.226	0.000^c
hOGG₁P			0.922	0.000^c
hOGG₁I	0.411	0.000^c			6.591E-02	0.008^c
Age	0.090	0.201	-0.139	0.108	-0.075	0.426	2.532E-02	0.001^c	3.069	0.018^c
Gender	-0.027	0.693	-0.081	0.336	-0.106	0.253	0.058	0.474	0.104	0.262
BMI	-0.046	0.496	-0.055	0.511	-1.048E-02	0.050^c	-0.053	0.516	0.037	0.696
hOGG₁ 326SNP	0.056	0.427	0.103	0.029^c	2.370E-03	0.000^c	-0.112	0.166	-15.684	0.006^c
Constant	0.480	0.000	6.969E-02	0.705	1.601	0.000	0.401	0.001	-133.512	0.001
R²(F)^d	0.667 (79.227)^e		0.470 (35.033)^e		0.377 (15.729)^e		0.509 (40.875)^e		0.386 (16.369) ^e

A: hOGG₁ 326SNP: Cys/Cys = 1; Cys/Ser = 2; Ser/Ser = 3; B: Beta: standardized coefficient; C: Variables entered final equation (backward); D: R square of model (F value of ANOVA); E: ANOVA P value < 0.01.

Citation: Peng T, Shen HM, Liu ZM, Yan LN, Peng MH, Li LQ, Liang RX, Wei ZL, Halliwell B, Ong CN. Oxidative DNA damage in peripheral leukocytes and its association with expression and polymorphisms of hOGG₁: A study of adolescents in a high risk region for hepatocellular carcinoma in China. World J Gastroenterol 2003; 9(10): 2186-2193
URL: https://www.wjgnet.com/1007-9327/full/v9/i10/2186.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i10.2186