Relationship between Egr-1 gene expression and apoptosis in esophageal carcinoma and precancerous lesions

Table 4 The relationship between the expression of Egr-1 and cell apoptosis and biological behavior in esophageal squamous cell carcinoma

Clinicopathologic data	n	Egr-1 positive n(%)	AI(cells/mm2)
Age(years)
≤ 50	20	6 (30.0)	21.5 ± 7.9
> 50	46	12 (26.1)	24.3 ± 8.8
Tumor site
Upper segment	4	0 (0)	20.4 ± 6.2
Middle segment	50	14 (28.0)	23.7 ± 9.3
Lower segment	12	4 (33.3)	21.5 ± 8.4
Lesion’s diameter(cm)
≤ 5	45	10 (22.2)	22.6 ± 8.5
> 5	21	8 (38.1)	22.3 ± 9.2
Differentiation degrees
GradeI	18	7 (38.9)	31.6 ± 9.3
GradeII	33	10 (30.3)	28.5 ± 8.9
GradeIII	13	0 (0)	7.2 ± 3.5
Keratinization
Negative	15	1 (6.7)	8.6 ± 3.2
Positive	51	17 (33.3)a	34.7 ± 9.4b
Invasive depth
Upper muscular layer	22	5 (22.7)	18.7 ± 7.5
Serosa	44	13 (29.5)	26.1 ± 9.2
Lymphatic metastasis
Negative	30	11 (36.7)	23.4 ± 8.6
Positive	36	7 (19.4)	20.8 ± 7.5
Bcl-X/L protein
Negative	19	10 (52.6)	29.4 ± 8.8
Positive	47	8 (17.0)c	13.5 ± 4.2d

^aP < 0.05, χ² = 4.15 vs compared with non-keratinized squamous carcinoma group, χ² test;

^bP < 0.01, t = 16.79 vs compared with non-keratinized squamous carcinoma group, Student’s t test;

^cP < 0.01, χ² = 8.65 vs compared with Bcl-X/_L protein negative group, χ² test;

^dP < 0.01, t = 7.54 vs compared with Bcl-X/_L pro-tein negative group, Student’s t test.