Mutational characteristics in consecutive passage of rapidly replicating variants of hepatitis A virus strain H2 during cell culture adaptation

Table 4 Differences in the genome sequence and amino acids of the HAV H2 K7 with HAV H2K7 P6, HAV H2K7 P12, HAV H2K7 P18 and HAV H2 K7 P22

Nucleotide position	Location	Nucleotide					Amino acids
		K7	K7P6	K7P12	K7P18	K7P22	K7	K7P6	K7P12	K7P18	K7P22
33	5'NTR	C	C	C	U	U
263	5'NTR	U	U	U	U	C
378	5'NTR	U	U	U	U	C
591	5'NTR	A	A	G	G	G
646	5'NTR	A	A	A	U	U
858	VP2	G	U	U	U	U	A	S	S	S	S
1178	VP2	C	U	U	U	U	I	I	I	I	I
4022	2B	T	C	C	C	C	I	I	I	I	I
4558	2C	A	A	A	A	C	Q	Q	Q	Q	P
4802	2C	U	U	U	U	C	A	A	A	A	A
4949	2C	A	A	A	A	U	T	T	T	T	T
4968	2C	A	C	C	C	C	N	H	H	H	H
5193	3A	C	U	U	U	U	R	C	C	C	C
5217	3A	G	G	G	G	U	A	A	A	A	S
5336	3C	G	G	G	G	A	L	L	L	L	L
5715	3C	A	A	A	G	G	T	T	T	A	A
6427	3D	U	U	U	G	G	V	V	G	G	G
7256	3D	A	U	U	U	U	A	A	A	A	A