DNA immunization with fusion genes encoding different regions of hepatitis C virus E2 fused to the gene for hepatitis B surface antigen elicits immune responses to both HCV and HBV

Figure 1 Schematic diagram of the expression plasmids. The coordinates below the bars refer to the corresponding amino acid residues of HBV surface antigen (HBsAg) and HCV E2 protein. The fusion genes were under the control of CMV immediate early promoter in pcDNA3. Bovine growth hormone (bGH) 3’-untranslated sequences were used as polyadenylation signals.