Chiral metabolism of propafenone in rat hepatic microsomes treated with two inducers

Table 5 The stereoselective effects of nimodipine on metabolic depletion of propafenone (mean ± SD, n = 3)

Group	Nimodipine/mg•L¯¹	S (+)-propafenone	R (-)-propafenone/mg•L¯¹	S/R
DEX	0	2.10 ± 0.04	1.75 ± 0.14a	1.20
DEX	8	2.32 ± 0.26	2.10 ± 0.21b	1.1
0DEX	16	3.81 ± 0.11c	3.62 ± 0.13c	1.0
6DEX	32	4.30 ± 0.13c	4.17 ± 0.26c	1.03

^aP < 0.01, vs S(+)-propafenone in DEX without nimodipine;

^bP < 0.05,

^cP < 0.001, vs the corresponding enantiomer in DEX without nimodipine.