Chiral metabolism of propafenone in rat hepatic microsomes treated with two inducers

Table 4 Enzymatic parameters in propafenone enantiomer metabolism in vitro (mean ± SD, n = 3)

Pretreat	Enantiomer	Km/μmol•L¯¹	υmax/μmol•g¯¹•min-1	Clint in prot/L μmin-1•g¯¹
Control	S (+)	94 ± 7	0.72 ± 0.07	7.6 ± 0.7
	R (-)	83 ± 6	0.75 ± 0.16	8.9 ± 1.1
Dex	S (+)	118 ± 16ab	1.04 ± 0.09c	8.9 ± 0.9a
	R (-)	86 ± 11d	0.93 ± 0.06	10.9 ± 0.8b
BNF	S (+)	128 ± 14ac	1.07 ± 0.20 b	8.3 ± 0.7a
	R (-)	105 ± 6c	1.04 ± 0.15b	9.9 ± 0.9

^aP < 0.05, vs R (-)-propafenone;

^bP < 0.05,

^cP < 0.01, vs corresponding enantiomer in control;

^dP < 0.05, vs R (-)-isomer in BNF.