Chiral metabolism of propafenone in rat hepatic microsomes treated with two inducers

Table 3 Ratio of S (+)/R (-) propafenone concentration in rat li ver microsomal incubates (mean ± SD, n = 3)

Group	t (incubation)/min
	0	3	8	20	30 (min)
Control	1.000	1.017 ± 0.010	0.997 ± 0.016	1.006 ± 0.012	1.016 ± 0.016
Dex	1.000	1.007 ± 0.003	1.044 ± 0.011d	1.076 ± 0.019	1.170 ± 0.050abc
BNF	1.000	1.005 ± 0.002	1.031 ± 0.012d	1.068 ± 0.023	1.094 ± 0.017ac

^aP < 0.01, vs 8 min;

^bP < 0.05, vs BNF group;

^cP < 0.01,

^dP < 0.05, vs control.