Chiral metabolism of propafenone in rat hepatic microsomes treated with two inducers

Table 2 Ratio of S (+)/R (-) propafenone at different concentrations in rat liver microsomal incubates (mean ± SD, n = 3)

Enantiomer/mg•L¯¹	Pretreat
	Control	Dex	BNF
5	1.016 ± 0.016	1.177 ± 0.062ab	1.104 ± 0.019ab
10	1.029 ± 0.012	1.103 ± 0.057	1.069 ± 0.015
20	0.995 ± 0.016	1.088 ± 0.018	1.053 ± 0.002
40	0.974 ± 0.026	1.057 ± 0.030	1.043 ± 0.000
80	0.978 ± 0.024	1.019 ± 0.017	1.027 ± 0.005
160	0.988 ± 0.012	1.003 ± 0.019	1.005 ± 0.005

^aP < 0.01, vs control;

^bP < 0.01, vs 160 mg•L¯¹.