Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas

Table 12 Comparison of cell-function differentiation classification and molecular biological features of gastric carcinoma with liver or ovary metastases

Comparison	GC with liver mets.	GC with ovary mets.
	Positive/12 cases (%)	Positive/14 cases (%)
Cell-function differentiation types
AFDT	9 (75.0)a	0
MSFDT	1 (8.3)	2 (14.3)
AMPFDT	1 (8.3)	12 (85.7)b
SFDT	1 (8.3)	0
NFDT	0	0
Comparison of molecular biological features
Estrogen-dependent ER (+)	0	12 (85.7)c
LN (+) BM structure (+)	12 (100.0)	0
Mutant p53 protein (+)	10 (83.3)d	3 (21.4)
DNA ploidy:Diploid	3 (25.0)	10 (71.4)
Tetraploid	0	2 (14.3)
Aneuploid	9 (75.0)e	2 (14.3)
CD44v6 expression (+)	10 (83.3)f	0

LN: Laminin; BM: Basement membrane; Mets: Metastasis

^aP < 0.01 (Exact test χ² = 12.9160), vs AFDT with ovary mets;

^bP < 0.01 (Exact test χ² = 12.5357), vs AMPFDT with liver mets;

^cP < 0.01 (Exact test χ² = 15.8087), vs GC with liver mets;

^dP < 0.01 (Exact test χ² = 7.5833), vs GC with ovary mets;

^eP < 0.01 (Exact test χ² = 6.0420), vs GC with ovary mets;

^fP < 0.05 (Exact test χ² = 15.6010), vs GC with ovary mets.