Treatment revisited and factors affecting prognosis of severe acute pancreatitis

Table 2 Effects of Octreotide and the herbal medicinals

Drug	Effects
Octreotide	Inhibits release of CCK and pancreatic enzymes
(Sandostatin)[5]	Stimulates and activates macrophages, lowering endotoxin level[6]
	Blocks release of inflammatory cytokines[7]
	Redistributes intrapancreatic blood flow
	Attenuates the interaction of neutrophils and endothelial cells[8]
	Inhibits eicosanoid and products as PGI2, leucotrienes
	Relaxes Oddi’s sphincter
Bulpleurum	Inhibits secretion and activities of pancreatic enzymes
Peony	Stabilizes lysosomal membrane
Cheng Qi	Inhibits inflammatory cytokines, IL-1, IL-6, IL-8, and TNF-α;
decoction[5]	Inhibits vascular permeability[9]
	Increase peristalsis with purgating effect, expelling bacterial flora
	and endotoxin
	Protects gut mucosal barrier, preventing bacteria dislocation[10,11]
	Relaxes Oddi’s sphincter
	Reduces urea synthesis, promotes urinary excretion of urea and
	creatinine
	Has broad antibiotic spectrum, including B. Fragilis
	Stimulates secretion of endogenous glucocorticoids which can inhibit
	cytokines and inflammatory mediators
	Decreases blood lipids, inhibits lipid peroxidation
	Inhibits TXA2 synthase, promotes PGE1 PGE2 levels, inhibits
	transformation of fibrinogen to fibrin and prevents endotoxin
	induced DIC
Dan Shen	Inhibits platelet aggregation, decreases blood viscosity, improves
(Salvia	blood rheology and microcirculation
Miltiorrhiza)	Inhibits lysosomal enzymes and chemotactic neutrophils
	Blockage of calciumion influx
	Has antioxidation effect, ameliorates inflammation and tissue damage