Research on optimal immunization strategies for hepatitis B in different endemic areas in China

Table 1 Benefit of HB vaccination of the low-dose strategy for three places with different economic development level and different endemicity

	Place
	Longan	Shanghai	Jinan
HBsAg positive rate before vaccination (%)	18.0	10.2	7.6
No. of neonates in 1987	7666	12000	18519
Direct benefit*	286	345	562
Indirect benefit*	683	1571	1852
Total benefit*	969	1916	2414
Total cost*	18	22	42
Net benefit*	951	1893	2372
BCR	52.7	85.8	57.9
DBCR	15.5	15.4	13.5
BCR excluding cost of liver cancer	23.6	67.9	34.8
DBCR excluding cost of liver cancer	9.2	14.2	10.1
HBsAg-positive rate after vaccination (%)	3.1	2.2	1.5

^*10000 Yuan RMB.