Clinicopathologic and biomolecular features of interval colorectal cancers in Korean patients: A KASID multicenter prospective study

doi:10.3748/wjg.127120

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jan 14, 2027; 33(2): 127120
Published online Jan 14, 2027. doi: 10.3748/wjg.127120

Table 4 The risk factors for survival of patients with colorectal cancer, after propensity score weighting

		Multivariable analysis
		HR	P value
Sex	Male	Reference	0.172
Sex	Female	1.83 (0.77-4.37)	0.172
Age at diagnosis		0.99 (0.95-1.02)	0.490
BMI		0.82 (0.70-0.96)	0.014
Family history of CRC	No	Reference	0.710
Family history of CRC	Yes	0.51 (0.01-1.79)	0.710
Smoking	None	Reference
	Ex-smoker	2.39 (0.71-8.05)	0.161
	Smoker	0.75 (0.10-5.82)	0.784
Alcohol	None	Reference	0.061
Alcohol	Yes	0.31 (0.10-1.06)	0.061
Comorbidity	None	Reference	0.071
Comorbidity	Yes	2.34 (0.93-5.88)	0.071
Size of cancer		1.00 (0.98-1.02)	0.952
Type of cancer	Sporadic cancer	Reference	0.786
Type of cancer	Interval cancer	0.83 (0.23-3.09)	0.786
Staging	I	Reference
	II	2.67 (0.27-19.20)	0.330
	III	9.58 (1.97-46.51)	0.005
	IV	25.36 (4.09-157.1)	< 0.001
CIMP	Negative	Reference	< 0.001
CIMP	Positive	45.15 (8.09-251.9)	< 0.001
KRAS	Wild type	Reference	0.547
KRAS	Non-wild type	1.34 (0.52-3.47)	0.547
MSI	MSS	Reference	< 0.001
MSI	MSI	1.27e^-8 (2e^-9-8.12e^-8)	< 0.001
BRAF	Negative	Reference	0.003
BRAF	Positive	0.08 (0.01-0.44)	0.003

CIMP: CpG island methylator phenotype; MSI: Microsatellite instability; MSS: Microsatellite-stable; BMI: Body mass index; CRC: Colorectal cancer; HR: Hazard ratio.

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Citation: Song JH, Shin JE, Kim DS, Lee YJ, Yang HC, Kim KO, Kim JH, Kang GH, Shim SR, Huh KC. Clinicopathologic and biomolecular features of interval colorectal cancers in Korean patients: A KASID multicenter prospective study. World J Gastroenterol 2027; 33(2): 127120
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/127120.htm
DOI: https://dx.doi.org/10.3748/wjg.127120

Song JH, Shin JE, Kim DS, Lee YJ, Yang HC, Kim KO, Kim JH, Kang GH, Shim SR, Huh KC. Clinicopathologic and biomolecular features of interval colorectal cancers in Korean patients: A KASID multicenter prospective study. World J Gastroenterol 2027; 33(2): 127120 [DOI: 10.3748/wjg.127120]

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