Clinicopathologic and biomolecular features of interval colorectal cancers in Korean patients: A KASID multicenter prospective study

Table 1 Comparison of clinicopathological features between interval and sporadic colorectal cancers, before and after propensity score weighting, n (%)

		Before PSW				After PSW
		Interval	Sporadic	P value	SMD	Interval	Sporadic	P value	SMD
		CRC (n = 28)	CRC (n = 79)			CRC (n = 23.60)	CRC (n = 67.48)
Clinical feature
Sex	Female	12 (42.9)	20 (25.3)	0.082	0.377	7.7 (32.4)	17.5 (25.9)	0.700	0.143
Age at diagnosis	Years, mean (SD)	66.61 (10.21)	66.00 (10.92)	0.798	0.057	68.95 (8.51)	66.71 (11.04)	0.376	0.228
BMI	kg/m2, mean (SD)	23.23 (3.66)	22.96 (3.31)	0.725	0.076	23.01 (3.22)	23.00 (3.40)	0.987	0.004
Smoking history	Non-smoker	20 (71.4)	39 (49.4)	0.08	0.54	14.1 (59.6)	35.7 (52.9)	0.293	0.608
	Ex-smoker	3 (10.7)	24 (30.4)			1.6 (6.9)	18.8 (27.8)
	Smoker	5 (17.9)	16 (20.3)			7.9 (33.5)	13.0 (19.3)
Alcohol history	Yes	11 (39.3)	29 (36.7)	0.809	0.053	12.1 (51.5)	24.2 (35.9)	0.420	0.318
Comorbidity	Yes	15 (53.6)	49 (62.0)	0.433	0.172	15.7 (66.4)	41.9 (61.9)	0.806	0.094
Family history	Yes	2 (7.1)	0 (0)	0.016	0.392	0.5 (2.2)	0 (0)	0.049	0.213
Pathological feature
Location of tumor	Left side	16 (57.1)	52 (65.8)	0.412	0.179	18.9 (80.0)	44.7 (66.2)	0.249	0.316
	Descending colon	0	2			0	1.5
	Sigmoid colon	10	26			10.5	24
	Rectum	6	24			8.4	19.2
	Right side	12 (42.9)	27 (34.2)			4.8 (20.0)	22.8 (33.8)
	Cecum	0	5			0	3.7
	Ascending colon	11	15			4.5	13.9
	Transverse colon	1	7			0.3	5.2
Size of tumor	mm, mean (SD)	39.43 (26.05)	46.84 (19.21)	0.115	0.324	39.28 (16.57)	45.43 (19.45)	0.117	0.341
Shape of tumor	Is	1 (3.6)	1 (1.3)	0.45	0.539	0.3 (1.1)	0.7 (1.1)	0.764	0.459
	Isp	0 (0.0)	1 (1.3)			0.0 (0.0)	0.7 (1.1)
	Ip	1 (3.6)	0 (0.0)			0.3 (1.1)	0.0 (0.0)
	LST-NG	2 (7.1)	1 (1.3)			0.5 (2.2)	0.7 (1.1)
	LST-G	1 (3.6)	1 (1.3)			0.3 (1.1)	0.7 (1.1)
	Fungating	9 (32.1)	23 (29.1)			7.2 (30.6)	19.7 (29.2)
	Ulcerative	4 (14.3)	16 (20.3)			7.9 (33.7)	13.7 (20.3)
	Ulceroinfiltrative	9 (32.1)	32 (40.5)			6.8 (28.9)	28.0 (41.6)
	Infiltrative	1 (3.6)	4 (5.1)			0.3 (1.3)	3.1 (4.6)
Differentiation	W/D	6 (21.4)	7 (8.9)	0.341	0.388	8.2 (34.9)	7.6 (11.3)	0.221	0.621
	M/D	19 (67.9)	61 (77.2)			14.0 (59.3)	50.7 (75.1)
	P/D	3 (10.7)	10 (12.7)			1.4 (5.8)	8.5 (12.5)
	Other	0 (0.0)	1 (1.3)			0 (0.0)	0.7 (1.1)

PSW: Propensity score weighting; CRC: Colorectal cancer; SMD: Standardized mean difference; Is: Sessile; Isp: Semi-pedunculated; Ip: Pedunculated; LST-NG: Laterally spreading tumor-nongranular; LST-G: Laterally spreading tumor-granular; W/D: Well-differentiated; M/D: Moderately differentiated; P/D: Poorly differentiated.