Lauric acid attenuates 14-day DDC-induced cholangiopathy in association with reduced NF-κB-CCL2 signaling and restored LRH-1-regulated gene expression

doi:10.3748/wjg.125044

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 14, 2027; 33(2): 125044
Published online Jan 14, 2027. doi: 10.3748/wjg.125044

Table 1 Liver, body weight, and diet intake by mouse group, mean ± SEM

Mouse group	Chow (n = 8)	DDC (n = 9)	Lauric acid (n = 6)	DDC/Lauric acid (n = 6)
Initial body weight (g)	23 ± 0.37	23.67 ± 0.55	24.00 ± 0.36	25.83 ± 0.95^c
Final body weight (g)	25.13 ± 0.91^b	17.99 ± 0.50	24.37 ± 0.49^b	17.73 ± 0.68
Liver weight (g)	1.24 ± 0.07^b	0.95 ± 0.01	1.15 ± 0.05^b	0.88 ± 0.05
Liver weight/final body weight ratio	0.04 ± 0.001	0.05 ± 0.001	0.05 ± 0.002	0.05 ± 0.001
Diet intake (g/day/mouse)	4.47 ± 0.2^a	2.94 ± 0.43	2.85 ± 0.05	2.65 ± 0.29

^aP < 0.05 vs all other groups.

^bP < 0.05 vs 3,5-diethoxycarbonyl-1,4-dihydrocollidine.

^cP < 0.05 vs Chow.

DDC: 3,5-diethoxycarbonyl-1,4-dihydrocollidine.

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Citation: Ghosh S, Devereaux MW, Anderson CC, Orlicky DJ, Sokol RJ. Lauric acid attenuates 14-day DDC-induced cholangiopathy in association with reduced NF-κB-CCL2 signaling and restored LRH-1-regulated gene expression. World J Gastroenterol 2027; 33(2): 125044
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/125044.htm
DOI: https://dx.doi.org/10.3748/wjg.125044

Ghosh S, Devereaux MW, Anderson CC, Orlicky DJ, Sokol RJ. Lauric acid attenuates 14-day DDC-induced cholangiopathy in association with reduced NF-κB-CCL2 signaling and restored LRH-1-regulated gene expression. World J Gastroenterol 2027; 33(2): 125044 [DOI: 10.3748/wjg.125044]

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