Serum pepsinogen combined with computed tomography imaging for diagnosing recurrence of gastric cancer after total gastrectomy

doi:10.3748/wjg.124537

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 14, 2027; 33(2): 124537
Published online Jan 14, 2027. doi: 10.3748/wjg.124537

Table 5 Tissue pepsinogen expression, serum pepsinogen levels, and computed tomography imaging findings in patients with recurrence stratified by histological type, n (%)

Histological Type	n	PG expression⁺	Serum PG⁺	CT imaging⁺
DGC	7	1 (14.29)	1 (14.29)	5 (71.43)
UGC	22	19 (86.36)	18 (81.82)	13 (59.09)
MADC	2	0 (0.00)	0 (0.00)	0 (0.00)
SRCC	3	3 (100.00)	3 (100.00)	2 (66.67)

Pepsinogen (PG) expression⁺ indicates positive immunohistochemical staining for PG I and/or PG II. Serum PG⁺ was defined as PG I > 26.93 ng/mL and/or PG II > 0.96 ng/mL. Computed tomography imaging+ indicates definitive signs of recurrence or metastasis. DGC: Differentiated gastric cancer; UGC: Undifferentiated gastric cancer; MADC: Mucinous adenocarcinoma; SRCC: Signet ring cell carcinoma; CT: Computed tomography; PG: Pepsinogen.

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Citation: Zhang JR, Xu XW, Liu JM, Zhu ZH, Mao CM. Serum pepsinogen combined with computed tomography imaging for diagnosing recurrence of gastric cancer after total gastrectomy. World J Gastroenterol 2027; 33(2): 124537
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/124537.htm
DOI: https://dx.doi.org/10.3748/wjg.124537

Zhang JR, Xu XW, Liu JM, Zhu ZH, Mao CM. Serum pepsinogen combined with computed tomography imaging for diagnosing recurrence of gastric cancer after total gastrectomy. World J Gastroenterol 2027; 33(2): 124537 [DOI: 10.3748/wjg.124537]

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