Fexuprazan vs esomeprazole for endoscopic submucosal dissection-induced gastric ulcer healing: A double-blind randomized controlled trial

Figure 1 Study protocol. All patients received intravenous esomeprazole 40 mg twice daily for the first 2 days after endoscopic submucosal dissection (ESD). Beginning on post-ESD day 3, patients were assigned to receive either oral fexuprazan 40 mg/day plus placebo esomeprazole or oral esomeprazole 40 mg/day plus placebo fexuprazan, administered once daily before breakfast for 8 weeks. Follow-up assessments included laboratory testing on days 1, 3, and 14 and upper gastrointestinal endoscopy at 4 weeks and 8 weeks after ESD to evaluate ulcer healing status. ESD: Endoscopic submucosal dissection.