Total bile acid better reflects the early biochemical biliary drainage response after endoscopic retrograde cholangiopancreatography

Table 3 Generalized estimating equation analyses of postoperative time effects after endoscopic retrograde cholangiopancreatography

Marker	Variable	β	SE	Wald χ2	P value
Tbil	Time: 24 hours after ERCP vs baseline	-0.025	0.020	1.567	0.211
	Time: 5 days after ERCP vs baseline	-0.229	0.023	98.944	< 0.001
Dbil	Time: 24 hours after ERCP vs baseline	-0.063	0.022	8.362	0.004
	Time: 5 days after ERCP vs baseline	-0.249	0.025	99.213	< 0.001
TBA	Time: 24 hours after ERCP vs baseline	-1.633	0.054	929.271	< 0.001
	Time: 5 days after ERCP vs baseline	-2.322	0.065	1265.955	< 0.001
GGT	Time: 24 hours after ERCP vs baseline	-0.074	0.015	24.117	< 0.001
	Time: 5 days after ERCP vs baseline	-0.269	0.018	217.510	< 0.001
ALP	Time: 24 hours after ERCP vs baseline	-0.044	0.008	27.219	< 0.001
	Time: 5 days after ERCP vs baseline	-0.145	0.011	163.313	< 0.001

Generalized estimating equation models were fitted separately for each marker and adjusted for diagnosis category and drainage strategy. Only the primary time effects comparing 24 hours after endoscopic retrograde cholangiopancreatography and 5 days after endoscopic retrograde cholangiopancreatography with baseline are shown. Negative coefficients indicate lower postoperative values relative to baseline. ERCP: Endoscopic retrograde cholangiopancreatography; Tbil: Total bilirubin; Dbil: Direct bilirubin; TBA: Total bile acid; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase.