Total bile acid better reflects the early biochemical biliary drainage response after endoscopic retrograde cholangiopancreatography

Table 1 Baseline characteristics according to early biochemical drainage response after endoscopic retrograde cholangiopancreatography, n (%)/mean ± SD

Variable	No response	Response	P value
n	618	278
Age, years	57.68 ± 14.32	57.50 ± 15.69	0.867
Male sex	411 (66.5)	178 (64.0)	0.518
Initial ERCP	442 (71.5)	238 (85.6)	< 0.001
Main diagnosis			0.001
Stone disease	436 (70.6)	225 (80.9)
Malignant stricture	89 (14.4)	36 (12.9)
Benign stricture	80 (12.9)	12 (4.3)
Other biliary disease	6 (1.0)	0 (0.0)
Clonorchiasis	5 (0.8)	4 (1.4)
Biliary dilation of unknown cause	2 (0.3)	1 (0.4)
Drainage strategy			< 0.001
ENBD only	347 (56.1)	203 (73.0)
ENBD + stent	87 (14.1)	26 (9.4)
No continuous drainage device	9 (1.5)	4 (1.4)
Stent only	175 (28.3)	45 (16.2)
Common bile duct diameter, mm	10.15 ± 6.01	11.53 ± 6.16	0.002
Stone clearance			< 0.001
No/partial clearance	47 (7.6)	14 (5.0)
Complete clearance	405 (65.5)	230 (82.7)
Baseline Tbil	87.75 ± 118.75	111.36 ± 98.09	0.004
Baseline Dbil	68.85 ± 99.26	85.42 ± 75.87	0.013
Baseline ALP	234.44 ± 213.50	269.77 ± 192.43	0.019
Baseline GGT	328.31 ± 349.96	539.38 ± 585.05	< 0.001
Baseline TBA	192.09 ± 270.53	315.57 ± 537.64	< 0.001
Baseline WBC	7.97 ± 4.14	9.37 ± 4.84	< 0.001

Early biochemical drainage response was defined according to the study criteria described in the Methods section. ERCP: Endoscopic retrograde cholangiopancreatography; ENBD: Endoscopic nasobiliary drainage; Tbil: Total bilirubin; Dbil: Direct bilirubin; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; TBA: Total bile acid; WBC: White blood cell count.