Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction

doi:10.3748/wjg.123795

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 14, 2027; 33(2): 123795
Published online Jan 14, 2027. doi: 10.3748/wjg.123795

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Figure 8 Proposed mechanism underlying the protective effects of melatonin against pathological angiogenesis in cirrhotic portal hypertension. Melatonin disrupts the interaction between POMK and VEGFR-2, resulting in reduced VEGFR-2 phosphorylation and attenuation of downstream PLC-γ/ERK1/2 signaling activation. This inhibition suppresses VEGF-induced endothelial cell proliferation and angiogenesis, thereby contributing to the improvement of splanchnic hyperdynamic circulation in cirrhotic portal hypertension. HUVEC: Human umbilical vein endothelial cell.

Citation: Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2027; 33(2): 123795
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/123795.htm
DOI: https://dx.doi.org/10.3748/wjg.123795

Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2027; 33(2): 123795 [DOI: 10.3748/wjg.123795]

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