Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction

doi:10.3748/wjg.123795

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 14, 2027; 33(2): 123795
Published online Jan 14, 2027. doi: 10.3748/wjg.123795

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Figure 7 Melatonin suppressed VEGFR-2 signaling via a POMK-dependent manner. A: Validation of VEGFR-2 knockdown by siRNA in human umbilical vein endothelial cells (HUVECs); B: Western blotting of VEGFR-2 signaling in HUVECs with VEGFR-2 knockdown; C and D: Quantitative analysis of PLCγ and ERK phosphorylation in B; E: Validation of POMK knockdown by siRNA in HUVECs; F: Western blotting of VEGFR-2 signaling in HUVECs with POMK knockdown; G-I: Quantitative analysis of VEGFR-2, PLCγ, and ERK phosphorylation in F. ^bP < 0.01. MLT: Melatonin.

Citation: Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2027; 33(2): 123795
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/123795.htm
DOI: https://dx.doi.org/10.3748/wjg.123795

Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2027; 33(2): 123795 [DOI: 10.3748/wjg.123795]

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