Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction

doi:10.3748/wjg.123795

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 14, 2027; 33(2): 123795
Published online Jan 14, 2027. doi: 10.3748/wjg.123795

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Figure 6 Melatonin suppressed VEGF signaling and interactions between VEGFR-2 and POMK. A: Western blotting of VEGFR-2 signaling in human umbilical vein endothelial cells (HUVECs) treated with VEGFA, melatonin, or AZD2171; B: Quantitative analysis of the activation of VEGFR-2 signaling; C: Immunoprecipitation (IP) blotting of VEGFR-2 in HUVECs and subjected of IP-mass spectrometry; D: PPI network of enriched proteins by IP-mass spectrometry; E: IP blotting of DOCK5 by VEGFR-2 in HUVECs; F: IP blotting of DSG1 by VEGFR-2 in HUVECs; G: IP blotting of POMK by VEGFR-2 in HUVECs; H: Quantitative analysis of IP blotting. ^aP < 0.05. ^bP < 0.01. MLT: Melatonin.

Citation: Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2027; 33(2): 123795
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/123795.htm
DOI: https://dx.doi.org/10.3748/wjg.123795

Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2027; 33(2): 123795 [DOI: 10.3748/wjg.123795]

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