Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction

doi:10.3748/wjg.123795

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 14, 2027; 33(2): 123795
Published online Jan 14, 2027. doi: 10.3748/wjg.123795

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Figure 5 Melatonin and AZD2171 inhibited angiogenesis in vitro. A: Western blotting of VEGFR-2 and its phosphorylated form in human umbilical vein endothelial cells (HUVECs) treated with VEGFA, melatonin (MLT), or AZD2171; B: Quantitative analysis of VEGFR-2 phosphorylation; C: The proliferation assay of HUVECs treated with VEGFA, MLT, or AZD2171; D: The tube formation assay of HUVECs treated with VEGFA, MLT, or AZD2171; E: Quantitative analysis of tube formation assay; F: The wound healing assay of HUVECs treated with VEGFA, MLT, or AZD2171; G: Quantitative analysis of wound healing assay; H: Transwell migration assay of HUVECs treated with VEGFA, MLT, or AZD2171; I: Quantitative analysis of Transwell migration assay. ^aP < 0.05. ^bP < 0.01. MLT: Melatonin.

Citation: Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2027; 33(2): 123795
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/123795.htm
DOI: https://dx.doi.org/10.3748/wjg.123795

Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2027; 33(2): 123795 [DOI: 10.3748/wjg.123795]

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