Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction

doi:10.3748/wjg.123795

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World Journal of Gastroenterology

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1007-9327

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 14, 2027; 33(2): 123795
Published online Jan 14, 2027. doi: 10.3748/wjg.123795

Table 1 Body weight and hemodynamic parameters, mean ± SD

Characteristics	Sham	Sham + MLT	BDL	BDL + MLT
Body weight (g)	408.5 ± 11.3	404.7 ± 12.0	349.2 ± 22.0^b	364.3 ± 20.2
MAP (mmHg)	119.5 ± 4.3	119.3 ± 8.9	99.2 ± 5.9^b	104.0 ± 6.3
PP (mmHg)	8.0 ± 0.9	7.7 ± 1.4	20.2 ± 2.9^b	14.5 ± 2.3^b
HR (beats/minute)	343 ± 23.4	336.8 ± 16.2	350.5 ± 14.6	349.3 ± 19.0
SV (mL/beats)	0.41 ± 0.04	0.42 ± 0.04	0.58 ± 0.08^b	0.43 ± 0.05^b
CO (mL/minute)	140.7 ± 9.6	137.1 ± 16.1	203.4 ± 31.3^b	149.3 ± 22.6^b
CI (mL/minute/100 g)	34.4 ± 2.7	34.0 ± 4.9	58.5 ± 10.1^b	41.1 ± 6.9^b
SVR (mmHg/mL/minute/100 g)	3.5 ± 0.3	3.6 ± 0.7	1.7 ± 0.4^b	2.6 ± 0.3^a
SMA flow (mL/minute/100 g)	3.1 ± 0.5	3.3 ± 0.5	6.4 ± 0.4^b	4.5 ± 0.5^b
SMA resistance (mmHg/mL/minute/100 g)	37.1 ± 6.1	35.0 ± 6.1	12.4 ± 1.5^b	20.0 ± 1.9^a

^aP < 0.05.

^bP < 0.01.

MLT: Melatonin; BDL: Bile duct ligation; MAP: Mean arterial pressure; HR: Heart rate; SMA: Superior mesenteric artery; SV: Stroke volume; SVR: Systemic vascular resistance; PP: Portal pressure; CO: Cardiac output; CI: Cardiac index.

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Citation: Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2027; 33(2): 123795
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/123795.htm
DOI: https://dx.doi.org/10.3748/wjg.123795

Wu GB, Luo GQ, Chen M, Cai KW, You XT, Han F, Zhang NZ, Luo M, Li Q, Huo HZ, Fan Q. Melatonin attenuates splanchnic hyperdynamic circulation in cirrhotic portal hypertension by disrupting POMK-VEGFR2 interaction. World J Gastroenterol 2027; 33(2): 123795 [DOI: 10.3748/wjg.123795]

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