Development and validation of a prognostic prediction model for alpha-fetoprotein-negative hepatocellular carcinoma with microvascular invasion after surgery

Table 3 Multivariable Cox regression analysis of overall survival in the training cohort

Variable	β-estimate (95%CI)	HR (95%CI)	P value
TBS (> 8.0 vs ≤ 8.0)	1.002 (0.503-1.501)	2.724 (1.654-4.486)	< 0.001
BCLC (B-C vs 0-A)		1.606 (0.915-2.817)	0.099
Fibrinogen, g/L (> 3.0 vs ≤ 3.0)		0.752 (0.459-1.230)	0.256
GMWG (> 22.7 vs ≤ 22.7)	0.586 (0.106-1.067)	1.797 (1.112-2.906)	0.017
NLR (> 2.3 vs ≤ 2.3)	0.775 (0.259-1.290)	2.170 (1.296-3.634)	0.003

TGN score = 1.002 × tumor burden score (0: ≤ 8.0; 1: > 8.0) + 0.586 × geometric mean of gamma-glutamyl transpeptidase and white blood cell (0: ≤ 22.7; 1: > 22.7) + 0.775 × neutrophil to lymphocyte ratio (0: ≤ 2.3; 1: > 2.3). Cut-offs to generate the risk groups: ≤ 0.6 (low), > 0.6 to ≤ 1.7 (intermediate), > 1.7 (high). HR: Hazard ratio; CI: Confidence interval; TBS: Tumor burden score; BCLC: Barcelona Clinic Liver Cancer; GMWG: Geometric mean of gamma-glutamyl transpeptidase and white blood cell; NLR: Neutrophil to lymphocyte ratio.