Development and validation of a prognostic prediction model for alpha-fetoprotein-negative hepatocellular carcinoma with microvascular invasion after surgery

doi:10.3748/wjg.123092

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World Journal of Gastroenterology

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1007-9327

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Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 14, 2027; 33(2): 123092
Published online Jan 14, 2027. doi: 10.3748/wjg.123092

Table 2 Univariate Cox regression analysis of overall survival in the training cohort

Variable	HR	95%CI	P value
Gender (male vs female)	0.877	0.381-2.017	0.758
Age, years (> 55 vs ≤ 55)	0.921	0.590-1.437	0.716
Alcohol abuse (yes vs no)	1.127	0.727-1.747	0.593
Smoking (yes vs no)	1.264	0.895-2.036	0.076
HBsAg (positive vs negative)	1.078	0.631-1.842	0.784
Liver cirrhosis (yes vs no)	1.248	0.584-2.663	0.567
TN (multiple vs single)	1.235	0.720-2.116	0.417
TBS (> 8.0 vs ≤ 8.0)	3.037	1.962-4.539	< 0.001
BCLC (B-C vs 0-A)	2.015	1.201-3.380	0.008
Fibrinogen, g/L (> 3.0 vs ≤ 3.0)	1.591	1.025-2.468	0.038
AST, U/L (> 40 vs ≤ 40)	0.832	0.488-1.525	0.611
GMWG (> 22.7 vs ≤ 22.7)	2.634	1.677-4.138	< 0.001
NLR (> 2.3 vs ≤ 2.3)	2.844	1.747-4.230	< 0.001

HR: Hazard ratio; CI: Confidence interval; HBsAg: Hepatitis B surface antigen; TN: Tumor number; TBS: Tumor burden score; BCLC: Barcelona Clinic Liver Cancer; AST: Aspartate aminotransferase; GMWG: Geometric mean of gamma-glutamyl transpeptidase and white blood cell; NLR: Neutrophil to lymphocyte ratio.

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Citation: Liao MJ, Zhou Y, Wang ZL, Wang XX, Ai X, Song LN, Fei R, Cong X, Liu F, Zhu PP, Chen HS, Liao WJ, Rao HY. Development and validation of a prognostic prediction model for alpha-fetoprotein-negative hepatocellular carcinoma with microvascular invasion after surgery. World J Gastroenterol 2027; 33(2): 123092
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/123092.htm
DOI: https://dx.doi.org/10.3748/wjg.123092

Liao MJ, Zhou Y, Wang ZL, Wang XX, Ai X, Song LN, Fei R, Cong X, Liu F, Zhu PP, Chen HS, Liao WJ, Rao HY. Development and validation of a prognostic prediction model for alpha-fetoprotein-negative hepatocellular carcinoma with microvascular invasion after surgery. World J Gastroenterol 2027; 33(2): 123092 [DOI: 10.3748/wjg.123092]

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