Surgical safety and efficacy of neoadjuvant immunotherapy plus apatinib and chemotherapy in locally advanced gastric cancer

doi:10.3748/wjg.122397

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 14, 2027; 33(2): 122397
Published online Jan 14, 2027. doi: 10.3748/wjg.122397

Table 5 Impact of indocyanine green fluorescence guidance on perioperative outcomes in the programmed cell death protein-1 inhibitors plus apatinib and chemotherapy group, median (interquartile range)/n (%)

Variable	ICG group (n = 28)	Non-ICG group (n = 36)	Statistic	P value
Age, years	63 (56-70)	61 (56-68)	-1.084	0.279
BMI, kg/m²	24.3 (22.7-25.5)	22.5 (20.6-24.7)	-1.901	0.057
Tumor location			4.248	0.120
Upper third	5 (17.9)	15 (41.7)
Middle third	12 (42.9)	10 (27.8)
Lower third	11 (39.3)	11 (30.6)
Tumor long diameter, cm	3.0 (2.0-4.6)	2.5 (2.0-5.0)	0.859	0.391
Resection range				0.576
Proximal gastrectomy	1 (3.6)	4 (11.1)
Distal gastrectomy	9 (32.1)	10 (27.8)
Total gastrectomy	18 (64.3)	22 (61.1)
Operative time, minutes	278 (208-300)	236 (215-277)	1.225	0.223
Intraoperative blood loss, mL	100 (95-143)	100 (80-120)	0.690	0.481
Intraoperative blood transfusion (yes), %	4 (14.3)	3 (8.3)		0.689
Multiorgan excision (yes), %	1 (3.6)	6 (16.7)		0.125
Conversion to open laparotomy (yes)	0 (0)	7 (19.4)		0.015
R0 resection (yes), %	26 (92.9)	34 (94.4)		1.000
Number of lymph nodes dissected	32 (24-33)	24 (21-26)	2.856	0.004
Proximal margin, cm	4.0 (2.1-5.2)	3.5 (2.0-5.1)	0.189	0.855
Distal margin, cm	5.7 (2.9-7.6)	6.2 (2.9-8.8)	-0.724	0.473
Postoperative complication (yes), %	6 (21.4)	8 (22.2)	0.000	0.939
Major complications (grade ≥ III)	3 (10.7)	3 (8.3)		1.000
Postoperative hospital stays, days	9 (8-9)	9 (8-10)	-0.778	0.423
Time to first, days
Aerofluxus	3 (2-3)	3 (2-3)	-0.007	1.000
Defecation	4 (3-5)	4 (4-5)	0.020	0.989
Enteral nutrition	3 (3-3)	3 (3-3)	-0.409	0.682
Liquid food	7 (6-7)	7 (6-7)	0.196	0.839
Removal of nasogastric tube	5 (5-6)	5 (5-6)	-0.097	0.923
Removal of abdominal drainage tube	9 (8-9)	9 (8-9)	0.717	0.431
Postoperative visual analog scale
Day 1	5 (4-5)	4 (4-5)	0.474	0.625
Day 2	2 (2-3)	3 (2-3)	-0.731	0.431
Day 3	2 (2-3)	3 (2-3)	-1.759	0.043
Day 5	0 (0-1)	0 (0-1)	0.068	0.944

BMI: Body mass index; ICG: Indocyanine green.

Full Size Table

Citation: Cheng ZW, Wei M, Zhang Y, Liang YZ, Cao WB, Zhao RD, Yan ZB, Sun GR, Cui XH, Yu WB. Surgical safety and efficacy of neoadjuvant immunotherapy plus apatinib and chemotherapy in locally advanced gastric cancer. World J Gastroenterol 2027; 33(2): 122397
URL: https://www.wjgnet.com/1007-9327/full/v33/i2/122397.htm
DOI: https://dx.doi.org/10.3748/wjg.122397

Cheng ZW, Wei M, Zhang Y, Liang YZ, Cao WB, Zhao RD, Yan ZB, Sun GR, Cui XH, Yu WB. Surgical safety and efficacy of neoadjuvant immunotherapy plus apatinib and chemotherapy in locally advanced gastric cancer. World J Gastroenterol 2027; 33(2): 122397 [DOI: 10.3748/wjg.122397]

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