Early chemotherapy after endoscopic retrograde cholangiopancreatography and survival in advanced pancreatic cancer with biliary obstruction

Table 2 Multivariable model for chemotherapy initiation within 30 days

Variable	OR (95%CI)	P value
Baseline TBil (μmol/L)	0.28 (0.09-0.73)	0.008
Baseline CRP (mg/L)	1.04 (0.56-1.97)	0.892
KPS/10	0.85 (0.43-1.57)	0.615
Baseline albumin (g/L)	0.98 (0.85-1.11)	0.707
Stage IV	1.80 (0.59-5.67)	0.297

The outcome was chemotherapy initiation within 30 days after endoscopic retrograde cholangiopancreatography. Odds ratios and 95%CIs were estimated using Firth penalized logistic regression. Baseline total bilirubin and C-reactive protein were log-transformed for modeling, and Karnofsky Performance Status score was scaled per 10-point increase. Stage III/Locally advanced disease was used as the reference category for stage. An odds ratio > 1 indicates a higher likelihood of chemotherapy initiation within 30 days, whereas an odds ratio < 1 indicates a lower likelihood. KPS: Karnofsky Performance Status; TBil: Total bilirubin; CRP: C-reactive protein; OR: Odds ratio.