Leucine-rich alpha-2 glycoprotein reflects transmural inflammation assessed by through-the-scope endoscopic ultrasonography: A prospective study in small-bowel Crohn’s disease

Figure 3 Receiver operating characteristic curves for assessing transmural inflammation in the overall cohort and clinical remission. A-D: In the overall cohort: Biomarkers for total wall thickness (TWT) ≥ 2.65 mm (A); Biomarkers for submucosal thickness (SMT) ≥ 0.95 mm (B); Disease activity indices for TWT ≥ 2.65 mm (C); Disease activity indices for SMT ≥ 0.95 mm (D); E and F: In clinical remission: Biomarkers for TWT ≥ 2.65 mm (E); Biomarkers for SMT ≥ 0.95 mm (F). TWT: Total wall thickness; SMT: Submucosal thickness; CRP: C-reactive protein; LRG: Leucine-rich alpha-2 glycoprotein; FC: Fecal calprotectin; AUC: Area under the curve; CDAI: Crohn’s disease activity index; SES-CD: Simple endoscopic score for Crohn’s disease.