Leucine-rich alpha-2 glycoprotein reflects transmural inflammation assessed by through-the-scope endoscopic ultrasonography: A prospective study in small-bowel Crohn’s disease

Table 3 Area under the curve, cutoff values, sensitivity, specificity among patients in clinical remission, n (%)

Outcome	n	Variable	AUC	95%CI	P value	Cutoff	Sn	Sp
TWT ≥ 2.65 mm	37 (47.4)	LRG	0.871	0.794-0.948	< 0.0001	13.99 μg/mL	0.703	0.951
		CRP	0.732	0.614-0.849	< 0.0001	1.02 mg/L	0.784	0.659
		FC	0.827	0.732-0.922	< 0.0001	118.24 μg/g	0.703	0.854
SMT ≥ 0.95 mm	26 (33.3)	LRG	0.875	0.790-0.960	< 0.0001	15.72 μg/mL	0.692	0.942
		CRP	0.699	0.576-0.822	0.001	1.04 mg/L	0.808	0.596
		FC	0.837	0.733-0.940	< 0.0001	162.39 μg/g	0.769	0.846

Missing C-reactive protein and fecal calprotectin values were imputed using predictive mean matching before receiver operating characteristic analysis. AUC: Area under the curve; CI: Confidence interval; Sn: Sensitivity; Sp: Specificity; TWT: Total wall thickness; SMT: Submucosal thickness; CRP: C-reactive protein; LRG: Leucine-rich alpha-2 glycoprotein; FC: Fecal calprotectin.