Leucine-rich alpha-2 glycoprotein reflects transmural inflammation assessed by through-the-scope endoscopic ultrasonography: A prospective study in small-bowel Crohn’s disease

Table 2 Area under the curve, cutoff values, sensitivity, specificity in the overall cohort, n (%)

Outcome	n	Variable	AUC	95%CI	P value	Cutoff	Sn	Sp
TWT ≥ 2.65 mm	81 (61.3)	LRG	0.875	0.816-0.935	< 0.0001	14.68 μg/mL	0.753	0.922
		CRP	0.732	0.641-0.822	< 0.0001	1.12 mg/L	0.753	0.686
		FC	0.847	0.780-0.913	< 0.0001	124.89 μg/g	0.778	0.824
		SES-CD	0.870	0.808-0.933	< 0.0001	2	0.914	0.784
		CDAI	0.769	0.687-0.851	< 0.0001	133.5	0.642	0.784
SMT ≥ 0.95 mm	64 (48.4)	LRG	0.833	0.764-0.902	< 0.0001	15.80 μg/mL	0.750	0.838
		CRP	0.720	0.631-0.810	< 0.0001	1.17 mg/L	0.781	0.647
		FC	0.837	0.766-0.908	< 0.0001	224.54 μg/g	0.766	0.853
		SES-CD	0.847	0.780-0.913	< 0.0001	4.5	0.813	0.779
		CDAI	0.756	0.675-0.837	< 0.0001	136.5	0.688	0.735

Missing C-reactive protein and fecal calprotectin values were imputed using predictive mean matching before receiver operating characteristic analysis. AUC: Area under the curve; CI: Confidence interval; Sn: Sensitivity; Sp: Specificity; TWT: Total wall thickness; SMT: Submucosal thickness; CRP: C-reactive protein; LRG: Leucine-rich alpha-2 glycoprotein; FC: Fecal calprotectin; CDAI: Crohn’s disease activity index; SES-CD: Simple endoscopic score for Crohn’s disease.