Gut microbiota signatures in colorectal cancer: Evidence synthesis from umbrella review and probiotic intervention studies

Table 4 17 microbial genera were significantly associated with colorectal cancer risk according to second-order meta-analysis (P ≤ 0.05, k ≥ 5)

Taxon	Outcome	k meta	Effects (n)	Pooled effect	CI low	CI high	P value	I2 value	τ2 value	QE test P value
Parvimonas	CRC/control	9	9	1.227	0.09	2.365	0.034	99.999	2.97	0
Fusobacterium	CRC/control	8	8	0.917	0.139	1.696	0.021	99.999	1.129	0
Hungatella	CRC/control	5	5	0.885	0.425	1.346	1.62 × 10-4	91.939	0.248	2.76 × 10-10
Anaerococcus	CRC/control	5	5	0.756	0.22	1.292	0.006	98.816	0.349	8.30 × 10-6
Gemella	CRC/control	8	8	0.616	0.287	0.945	2.39 × 10-4	99.998	0.22	0
Clostridium	CRC/control	9	9	0.508	0.129	0.888	0.009	100	0.327	0
Prevotella	CRC/control	10	10	0.429	0.161	0.697	0.002	99.999	0.173	0
Anaerotruncus	CRC/control	7	7	0.423	0.046	0.8	0.028	99.997	0.25	0
Parabacteroides	CRC/control	7	7	0.42	0.041	0.799	0.03	99.995	0.257	0
Dialister	CRC/control	5	5	0.401	0.051	0.751	0.025	99.996	0.153	0
Peptostreptococcus	CRC/control	6	6	0.398	0.27	0.526	9.96 × 10-10	81.662	0.014	7.06 × 10-4
Methanobrevibacter	CRC/control	5	5	0.398	0.042	0.753	0.028	96.741	0.13	0
Slackia	CRC/control	5	5	0.393	0.076	0.709	0.015	98.302	0.125	0
Bilophila	CRC/control	6	6	0.384	0.068	0.7	0.017	97.399	0.147	0
Bacteroides	CRC/control	10	10	0.355	0.092	0.619	0.008	99.999	0.176	0
Alistipes	CRC/control	9	9	0.353	0.049	0.657	0.023	99.994	0.206	0
Streptococcus	CRC/control	9	9	0.296	0.047	0.545	0.02	99.997	0.134	0

CI: Confidence interval; CRC: Colorectal cancer.