Identification of UPB1 as a tumor suppressor associated with immune infiltration in cholangiocarcinoma

Figure 2 The down-regulation of UPB1 is associated with unfavorable clinical characteristics and outcomes in cholangiocarcinoma. A: UPB1 expression was significantly correlated with tumor differentiation, lymphnodes metastasis and tumor node metastasis stage of cholangiocarcinoma (CCA); B and C: Kaplan-Meier analyses showed CCA patients with low expression of UPB1 had inferior overall survival (OS) (B) and disease-free survival (DFS) (C) than those with high expression; D and E: Multivariate Cox regression analyses showed low expression of UPB1 was independent risk factor for OS (D) and DFS (E) of CCA patients. TNM: Tumor node metastasis; OS: Overall survival; DFS: Disease-free survival; CA19-9: Carbohydrate antigen 19-9; CI: Confidence interval.