Identification of UPB1 as a tumor suppressor associated with immune infiltration in cholangiocarcinoma

Figure 1 UPB1 is down-regulated in cholangiocarcinoma. A: Low-expression of UPB1 was identified in cholangiocarcinoma (CCA) in Gene Expression Profiling Interactive Analysis database; B: Down-regulation of UPB1 was identified in CCA in four Gene Expression Omnibus datasets (GSE26566, GSE32225, GSE32958 and GSE76311); C: The messenger RNA expression levels of UPB1 were evaluated in 20 pairs of CCA and normal bile duct tissue samples; D: Representative images of UPB1 staining in CCA specimens and normal bile duct tissues; E and F: H scores of immunohistochemistry showed protein levels of UPB1 were down-regulated in both intrahepatic CCA and extrahepatic CCA tissues. T: Tumor; N: Normal; GEPIA: Gene Expression Profiling Interactive Analysis; mRNA: Messenger RNA; iCCA: Intrahepatic cholangiocarcinoma; eCCA: Extrahepatic cholangiocarcinoma.