Mechanisms of Fuling Zexie decoction against metabolic dysfunction-associated steatotic liver disease: Integrative metabolomics, gut microbiota and serum pharmacochemistry

doi:10.3748/wjg.123034

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2027. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Jan 7, 2027; 33(1): 123034
Published online Jan 7, 2027. doi: 10.3748/wjg.123034

Table 1 Orthogonal least partial squares discriminant analysis model parameters

Model	Group	R²Y value			Q² value
Model	Group	Serum	Liver	Urine	Serum	Liver	Urine
ESI+	CON vs MOD	0.998	0.998	0.998	0.777	0.866	0.968
ESI+	FZD vs MOD	0.997	0.994	0.997	0.799	0.412	0.962
ESI-	CON vs MOD	0.998	0.992	0.993	0.873	0.882	0.962
ESI-	FZD vs MOD	0.999	0.998	0.998	0.906	0.576	0.979

CON: Control group; MOD: Model group; FZD: Fuling Zexie decoction group; ESI: Electrospray ionization; ESI+: Positive ion model; ESI-: Negative ion model.

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Citation: Wang PQ, Yang H, Tang YM, Tao YX, Han SC, Zhou QD, Yu J, Yang XX. Mechanisms of Fuling Zexie decoction against metabolic dysfunction-associated steatotic liver disease: Integrative metabolomics, gut microbiota and serum pharmacochemistry. World J Gastroenterol 2027; 33(1): 123034
URL: https://www.wjgnet.com/1007-9327/full/v33/i1/123034.htm
DOI: https://dx.doi.org/10.3748/wjg.123034

Wang PQ, Yang H, Tang YM, Tao YX, Han SC, Zhou QD, Yu J, Yang XX. Mechanisms of Fuling Zexie decoction against metabolic dysfunction-associated steatotic liver disease: Integrative metabolomics, gut microbiota and serum pharmacochemistry. World J Gastroenterol 2027; 33(1): 123034 [DOI: 10.3748/wjg.123034]

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