Glasgow prognostic score as a predictor of decompensation in patients with primary biliary cholangitis

Table 3 Univariable and multivariable Cox regression analyses of the association between Glasgow prognostic scores and decompensation risk

Variable	Univariate analysis		Multivariate analysis
			Model A		Model B		Model C
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
GPS
0	Reference		Reference		Reference		Reference
1	5.593 (3.475-9.003)	< 0.001	5.805 (3.589-9.389)	< 0.001	5.911 (3.647-9.580)	< 0.001	5.540 (3.346-9.173)	< 0.001
2	14.289 (8.617-23.694)	< 0.001	13.618 (8.133-22.804)	< 0.001	13.942 (8.290-23.450)	< 0.001	13.573 (7.835-23.514)	< 0.001
P for trend	3.690 (2.922-4.660)	< 0.001	3.595 (2.837-4.556)	< 0.001	3.654 (2.875-4.643)	< 0.001	3.605 (2.783-4.670)	< 0.001
mGPS
0	Reference		Reference		Reference		Reference
1	7.747 (4.755-12.62)	< 0.001	8.512 (5.169-14.016)	< 0.001	8.537 (5.180-14.070)	< 0.001	8.025 (4.805-13.405)	< 0.001
2	10.09 (6.546-15.551)	< 0.001	9.219 (5.926-14.340)	< 0.001	9.511 (6.082-14.873)	< 0.001	8.459 (5.211-13.732)	< 0.001
P for trend	3.238 (2.644-3.965)	< 0.001	3.128 (2.544-3.846)	< 0.001	3.188 (2.584-3.932)	< 0.001	3.103 (2.469-3.900)	< 0.001
hs-mGPS
0	Reference		Reference		Reference		Reference
1	7.161 (4.291-11.952)	< 0.001	7.315 (4.349-12.305)	< 0.001	7.307 (4.322-12.353)	< 0.001	7.343 (4.269-12.630)	< 0.001
2	12.224 (7.523-19.862)	< 0.001	11.951 (7.257-19.679)	< 0.001	12.187 (7.382-20.120)	< 0.001	11.407 (6.669-19.511)	< 0.001
P for trend	3.283 (2.639-4.084)	< 0.001	3.245 (2.591-4.064)	< 0.001	3.300 (2.628-4.143)	< 0.001	3.261 (2.549-4.171)	< 0.001

Model A: Adjusted for age, sex, body mass index. Model B: Adjusted for all variables in model A plus hypertension, diabetes mellitus, and atherosclerosis. Model C: Adjusted for all variables in model B plus total bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, international normalized ratio, anti-mitochondrial antibody M2, anti-nuclear dot protein SP100 antibody, and anti-glycoprotein 210 antibody. Total bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase and international normalized ratio were treated as continuous variables, whereas anti-mitochondrial antibody M2, anti-nuclear dot protein SP100 antibody, and anti-glycoprotein 210 antibody were treated as categorical variables. CI: Confidence interval; GPS: Glasgow prognostic score; HR: Hazard ratio; hs-mGPS: High-sensitivity modified Glasgow prognostic score; mGPS: Modified Glasgow prognostic score.