Longitudinal serum total cholesterol patterns and subsequent clinical relapse in ulcerative colitis

Table 2 Subsequent relapse risk according to maximal serum total cholesterol levels at 1 year, 2 years, and 3 years after endoscopic improvement

Landmark time	Cutoff group	Patients		Univariable analysis		Multivariable analysis
		Non-relapse	Relapse	HR (95%CI)	P value	Adjusted HR (95%CI)	P value
1-year	< 4.53 mmol/L	82	29	Ref		Ref
	≥ 4.53 mmol/L	166	121	1.73 (1.15-2.60)	0.008	1.85 (1.11-3.07)	0.018
2-year	< 4.53 mmol/L	58	14	Ref		Ref
	≥ 4.53 mmol/L	181	90	1.88 (1.07-3.30)	0.028	2.05 (1.05-4.01)	0.036
3-year	< 5.56 mmol/L	148	28	Ref		Ref
	≥ 5.56 mmol/L	87	32	1.92 (1.16-3.18)	0.012	2.16 (1.11-4.22)	0.024

Hazard ratios and 95%CIs were estimated using Cox proportional hazards models for landmark analysis. The analyses were restricted to patients who were relapse-free at each landmark time point. Multivariable models were adjusted for age, sex, baseline serum total cholesterol, infliximab use, statin use, and Mayo endoscopic subscore 0/1. HR: Hazard ratio; Ref: Reference.