Research progress of plant-derived chemical compounds for overcoming pancreatic cancer drug resistance

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 7, 2026; 32(9): 115131
Published online Mar 7, 2026. doi: 10.3748/wjg.v32.i9.115131

Table 2 Summary of microRNAs associated with gemcitabine resistance in pancreatic cancer

Names of ncRNAs	Genomic location	Expression	Regulated chemotherapy drugs	Ref.
miR-210	11p15.5	Upregulated	GEM	[99]
miR-30a-3p	6q13	Upregulated	GEM	[100]
miR-146a-5p	5q33.3	Downregulated	GEM	[101]
miR-21	17q23.2	Upregulated	GEM	[102]
miR-221/222	Xp11.3	Upregulated	GEM	[103]
miR126	9q34.3	Downregulated	GEM	[104]
miR-497	17p13.1	Downregulated	GEM	[105]
miR-7	9q21.11	Downregulated	GEM	[106]
miR-136-5p	14q32.31	Downregulated	GEM	[107]
miR-3662	14q32.31	Downregulated	GEM	[108]
miR-499a-5p	20q11.22	Upregulated	5-FU	[109]
miR-1291-5p	12q24.31	Downregulated	DDP	[110]
miR-181a-5p	1q32.1	Upregulated	FOLFIRINOX	[111]
miR-1307	15q21.1	Downregulated	FOLFIRINOX	[112]

ncRNAs: Non-coding RNAs; GEM: Gemcitabine; 5-FU: 5-fluorouracil; DDP: Cisplatin; FOLFIRINOX: Fluorouracil, leucovorin, irinotecan, and oxaliplatin.

Citation: Yu JQ, Yu SJ, He YH, Xue YZ, Yu XF, Chen W, Hu LY, Fan XF, Gao ZF, Zhou HK, Liu XR, He XS, Wang XG. Research progress of plant-derived chemical compounds for overcoming pancreatic cancer drug resistance. World J Gastroenterol 2026; 32(9): 115131
URL: https://www.wjgnet.com/1007-9327/full/v32/i9/115131.htm
DOI: https://dx.doi.org/10.3748/wjg.v32.i9.115131

Yu JQ, Yu SJ, He YH, Xue YZ, Yu XF, Chen W, Hu LY, Fan XF, Gao ZF, Zhou HK, Liu XR, He XS, Wang XG. Research progress of plant-derived chemical compounds for overcoming pancreatic cancer drug resistance. World J Gastroenterol 2026; 32(9): 115131 [PMID: 41810441 DOI: 10.3748/wjg.v32.i9.115131]

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