Lianhe Xiaozhi ointment ameliorates metabolic dysfunction-associated steatotic liver disease via peroxisome proliferator-activated receptor alpha pathway activation

Table 2 Fasting blood glucose and serum biochemical results in mice, mean ± SEM

Variables	ND	HFD	L-LXO	H-LXO
ALT (U/L)	23.32 ± 2.34	44.98 ± 3.07c	32.10 ± 2.68c,e	28.10 ± 1.56a,f
AST (U/L)	11.60 ± 0.93	59.42 ± 4.31c	39.75 ± 5.60e	27.87 ± 2.86f
TG (mmol/L)	0.58 ± 0.07	0.84 ± 0.04a	0.61 ± 0.06d	0.66 ± 0.04d
TC (mmol/L)	2.57 ± 0.10	5.60 ± 0.25c	5.06 ± 0.42c	4.86 ± 0.54b
LDL-C (mmol/L)	0.41 ± 0.03	1.30 ± 0.09c	1.34 ± 0.19c	1.14 ± 0.18b
HDL-C (mmol/L)	2.34 ± 0.04	2.98 ± 0.16b	3.02 ± 0.14b	2.88 ± 0.14a
FBG (mmol/L)	8.70 ± 0.12	11.03 ± 0.28c	10.23 ± 0.36b	9.23 ± 0.21f

^aP < 0.05 vs normal diet group.

^bP < 0.01 vs normal diet group.

^cP < 0.001 vs normal diet group.

^dP < 0.05 vs high-fat diet group.

^eP < 0.01 vs high-fat diet group.

^fP < 0.001 vs high-fat diet group.

One-way analysis of variance was employed. Data are presented as means ± SEM (n = 8). ND: Normal diet; HFD: High-fat diet; L-LXO: Low-dose Lianhe Xiaozhi ointment; H-LXO: High-dose Lianhe Xiaozhi ointment; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; FBG: Fasting blood glucose; TC: Total cholesterol; TG: Triglyceride; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol.