Xing-Pi-Qing-Gan decoction alleviates alcoholic liver disease by down-regulating DDIT3 and restoring Nrf2/HO-1 antioxidant signaling: Multi-omics and experimental evidence

Figure 8 Effect of Xing-Pi-Qing-Gan decoction on the expression of pp38, DDIT3, Nrf2 and HO-1. A: The relative mRNA expression of p38, DDIT3, Nrf2, HO-1 in HepG2; B: The relative mRNA expression of p38, DDIT3, Nrf2, HO-1 in mice; C and D: Representative protein expression of Nrf2, p-p38, p38, HO-1 and DDIT3 in HepG2; E and F: Representative protein expression of Nrf2, p-p38, p38, HO-1 and DDIT3 in mice (n = 3-5). ^aP < 0.01 vs the ethanol-fed group; ^bP < 0.01 vs the control group; ^cP < 0.05 vs the ethanol-fed group. Ctr: Control; EtOH: Ethanol-fed; XPQG: Xing-Pi-Qing-Gan decoction; XPQG-L: Xing-Pi-Qing-Gan decoction-low; XPQG-M: Xing-Pi-Qing-Gan decoction-medium; XPQG-H: Xing-Pi-Qing-Gan decoction-high.