Xing-Pi-Qing-Gan decoction alleviates alcoholic liver disease by down-regulating DDIT3 and restoring Nrf2/HO-1 antioxidant signaling: Multi-omics and experimental evidence

Figure 5 Xing-Pi-Qing-Gan decoction inhibited alcohol-induced liver injury inflammation, apoptosis, and oxidative stress. A: The relative mRNA expression of inflammation in mice; B: Serum inflammatory factor levels were determined, respectively, by enzyme-linked immunosorbent assay; C: Effects of Xing-Pi-Qing-Gan decoction on the expression of relative mRNA expression in apoptosis , including Bcl-2, BAX, and Caspase-3; D: Protein expression of Bcl-2 and Caspase-3; E-G: Superoxide dismutase, glutathione and malondialdehyde levels in livers (n = 6-8). ^aP < 0.01 vs the ethanol-fed group; ^bP < 0.01 vs the control group; ^cP < 0.05 vs the ethanol-fed group. IL-6: Interleukin-6; IL-1β: Interleukin-1β; TNF-α: Tumor necrosis factor-α; EtOH: Ethanol-fed; XPQG: Xing-Pi-Qing-Gan decoction; SOD: Superoxide dismutase; GSH: Glutathione; MDA: Malondialdehyde.