Xing-Pi-Qing-Gan decoction alleviates alcoholic liver disease by down-regulating DDIT3 and restoring Nrf2/HO-1 antioxidant signaling: Multi-omics and experimental evidence

Figure 4 Xing-Pi-Qing-Gan decoction alleviated hepatic injury in alcoholic liver injury mice. A and B: Effects of Xing-Pi-Qing-Gan decoction (XPQG) on body weight gain: Liver weight (A) and liver weight/body weight ratio values (B); C-F: Serum alanine aminotransferase, aspartate aminotransferase, triglyceride and the levels of γ-glutamyl transferase in liver; G: The images of representative hematoxylin and eosin or Oil Red O stained liver sections (40 ×); H-J: Effects of XPQG on the expression of relative mRNA expression in liver in lipid synthesis, including SREBP-1c, ACC, FASN (n = 6-8). ^aP < 0.01 vs the ethanol-fed group; ^bP < 0.01 vs the control group; ^cP < 0.05 vs the ethanol-fed group. Ctr: Control; EtOH: Ethanol-fed; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; TG: Triglyceride; GGT: γ-glutamyl transferase; XPQG-L: Xing-Pi-Qing-Gan decoction-low; XPQG-M: Xing-Pi-Qing-Gan decoction-medium; XPQG-H: Xing-Pi-Qing-Gan decoction-high.