Progression after endoscopic treatment for type I gastric neuroendocrine tumors: A single-center retrospective study

Table 4 Univariate and multivariate cox regression analyses, n (%)

Variables	Single factor analysis			Multi-factor analysis
	HR	95%CI	P value	HR	95%CI	P value
Sex
Male	1.00	Reference		1.00	Reference
Female	1.57	0.82-3.01	0.174	1.36	0.67-2.73	0.394
Age
< 60	1.00	Reference
≥ 60	0.96	0.47-1.96	0.911
Lesion
< 6	1.00	Reference		1.00	Reference
≥ 6	1.83	0.96-3.48	0.065	1.64	0.83-3.25	0.158
Max-diameter
< 10 mm	1.00	Reference		1.00	Reference
≥ 10 mm	0.59	0.28-1.23	0.161	0.57	0.23-1.41	0.223
SSAs
No	1.00	Reference		1.00	Reference
Yes	0.40	0.18-0.88	0.022	0.38	0.17-0.90	0.027
Pathology
G1	1.00	Reference		1.00	Reference
G2	1.15	0.51-2.62	0.731	2.13	0.88-5.18	0.094
Horizontal margin
Negative	1.00	Reference		1.00	Reference
Positive	1.25	0.38-4.09	0.709	2.26	0.63-8.13	0.213
Vertical margin
Negative	1.00	Reference
Positive	1.31	0.18-9.59	0.793
Lymphovascular invasion
Negative	1.00	Reference		1.00	Reference
Positive	0.29	0.04-2.11	0.221	0.42	0.05-3.38	0.415
Perineural invasion
Negative	1.00	Reference		1.00	Reference
Positive	5.94	0.79-44.35	0.083	6.20	0.60-64.04	0.126
Invasion depth
M	1.00	Reference		1.00	Reference
SM	1.60	0.82-3.14	0.171	1.74	0.81-3.71	0.153
NLR
≥ 2	1.00	Reference		1.00	Reference
< 2	1.90	1.02-3.55	0.043	2.14	1.08-4.26	0.030

HR: Hazards ratio; CI: Confidence interval; SSAs: Somatostatin analogs; NLR: Neutrophil-to-lymphocyte ratio.