Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance

Figure 6 Effects of V8 and bortezomib on MGC-803 xenograft growth in vivo. A: Images of tumor xenograft from different treatment groups; B: Tumor volume was monitored for different treatment groups during experimental period; C: Tumor weight was calculated for different groups at the end of experiment; D-G: Immunohistochemistry was performed for analysis of LAMP1, Ki67 and cleaved-caspase-3 expression. Representative images (D) and quantified data (E-G) are shown (scale bar: 20 μm); H: Hematoxylin and eosin staining was performed in tissue sections from heart, liver and kidney. Representative images are shown (scale bar: 20 μm). ^aP < 0.05. ^bP < 0.01. ^cP < 0.001. NS: No significance; BTZ: Bortezomib; AOD: Average optical density.