New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis

Figure 4 Cox proportional-hazards regression curves for mortality at 90 days. After adjusting for age, sex, Bedside Index of Severity in Acute Pancreatitis score, computed tomography severity index score, infected pancreatic necrosis, open pancreatic necrosectomy, major complications, multiple organ failure on admission, organ failure duration > 2 weeks, new-onset single organ failure (hazard ratio = 6.8, 95% confidence interval: 1.4-33.5, P = 0.019), and new-onset multi-organ failure (hazard ratio = 33.2, 95% confidence interval: 9.4-117.3, P < 0.001) were significantly associated with 90-day mortality in severe acute pancreatitis patients. OF: Organ failure; NOSOF: New-onset single organ failure; NOMOF: New-onset multi-organ failure.