New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis

Table 1 Comparison of baseline and clinical characteristics among new-onset multi-organ failure, new-onset single organ failure, and organ failure groups, n (%)

Characteristics	NOOF (n = 38)		OF (n = 113)	P value1	P value2
	NOMOF (n = 21)	NOSOF (n = 17)
Age, years, median (IQR)	42 (35, 67)	48 (35, 59)	48 (37, 59)	0.663	0.791
Male	10 (47.6)	11 (64.7)	55 (48.7)	0.482	0.292
BMI, mean ± SD	25.6 ± 2.8	26.5 ± 2.8	26.4 ± 3.1	0.466	0.332
Etiology				0.186	0.652
Biliary	10 (47.6)	7 (41.2)	33 (29.2)
Hypertriglyceridemia	7 (33.3)	8 (47.1)	52 (46.0)
Others	4 (19.0)	2 (11.8)	28 (24.8)
Severity
APACHE II score, median (IQR)	14 (11, 19)	16 (13, 20)	11 (8, 14)	< 0.001a	0.263
BISAP score, median (IQR)	3 (3, 4)	3 (2, 3)	2 (2, 3)	0.001a	0.117
CTSI score, median (IQR)	8 (8, 10)	8 (6, 10)	4 (4, 6)	< 0.001a	0.348
MOF on admission	12 (57.1)	9 (52.9)	19 (16.8)	< 0.001a	0.796
OF duration > 2 weeks	19 (90.5)	10 (58.8)	17 (15.0)	< 0.001a	0.058
IPN	19 (90.5)	14 (82.4)	19 (16.8)	< 0.001a	0.800
Major complications	15 (71.4)	11 (64.7)	13 (11.5)	< 0.001a	0.658
Interventions
Step-up approach	14 (66.7)	11 (64.7)	20 (17.7)	< 0.001a	0.899
OPN	5 (23.8)	3 (17.6)	0 (0)	< 0.001a	0.950

^aP < 0.05.

¹Group new-onset organ failure vs organ failure.

²Group new-onset multi-organ failure vs new-onset single organ failure.

NOOF: New-onset organ failure; OF: Organ failure; NOMOF: New-onset multi-organ failure; NOSOF: New-onset single organ failure; IQR: Interquartile range; BMI: Body mass index; APACHE: Acute physiology and chronic health assessment; BISAP: Bedside Index of Severity in Acute Pancreatitis; CTSI: Computed tomography severity index; MOF: Multiple organ failure; IPN: Infected pancreatic necrosis; OPN: Open pancreatic necrosectomy.